Successful reversal of complex regional pain syndrome type 1 of both upper extremities in five patients.

Bilateral complex regional pain syndrome (CRPS) appears to be unusual [1–5]. We report details of bilateral CRPS diagnosed by International Association for Study of Pain (IASP) criteria in five patients who presented with florid symptoms (more prominent in one extremity) that persisted despite physical therapy (PT) and medications (Figure 1). They were effectively treated with a novel multimodality treatment regimen (MMTR) developed from our experience in over a hundred patients of CRPS-1 in the last 10 years.